Photopigment densitometry has been applied to the study of retinal function for over 60 years. With the advent of near diffraction-limited ophthalmoscopes that can resolve individual photoreceptors, it is possible to apply this technique to investigations that require high spatial localization.
We are using photopigment densitometry to study the functional effect of visible light exposure on the retina. This research may have a significant impact on forthcoming laser safety standards for ophthalmic imaging.
We are currently developing this technique for use in patients with retinal disease. High-resolution photopigment densitometry can provide an objective measure of retinal function, which could allow us to track disease progression or identify patients for treatment.