The neural cells that line the back of our eyes are sensitive to light and initiate our ability to see. These cells are among the most metabolically active tissues in the human body and are nourished by a dense network of capillaries that circulate blood to deliver nutrients and remove waste products from these hard-working cells. However, dysfunction of this neural-vascular system associates with a variety of retinal diseases and collectively gives rise to the leading cause of blindness in the developed world.
Our lab investigates blood flow in the living eye by using a specialized camera called an Adaptive Optics Scanning Light Ophthalmoscope (AOSLO) to correct for small imperfections of the optics of the eye. Once corrected, we can image the microscopic integrity of the smallest vessels that are ten-times thinner than a human hair. Additionally, capturing videos of this tissue enables study of the movement of single blood cells flowing within this network. We are developing and applying this cutting-edge technology to study blood flow in the retina in conditions of health and disease.
Department of Ophthalmology
Department of Neurobiology and Anatomy
Center for Visual Science
University of Rochester
601 Elmwood Ave.
Rochester, NY 14642
Office: Medical Center G-4113
Telephone: (585) 273-4848
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Schallek J, McLellan G, Viswanathan S, Ts'o D (2012) Retinal Intrinsic Optical Signals in
a Cat Model of Primary Congenital Glaucoma. Invest Ophthal Vis Sci 53, 1971 –1981 PMID- 22395886
Schallek, J. and Ts'o, D. (2011) Blood Contrast Agents Enhance Intrinsic Signals in the
Retina: Evidence for an Underlying Blood Volume Component. Invest Ophthal Vis Sci 52, 1325 -1335. PMID- 21051719
Schallek J, Li H, Kardon R, Kwon Y, Abramoff M, Soliz P, Ts'o D (2009a) Stimulus-
Evoked Intrinsic Optical Signals in the Retina: Spatial and Temporal Characteristics. Invest Ophthal Vis Sci 50:4865-4872. PMID-19420337
Schallek J, Kardon R, Kwon Y, Abramoff M, Soliz P, Ts'o D (2009b) Stimulus-Evoked
Intrinsic Optical Signals in the Retina: Pharmacologic Dissection Reveals Outer Retinal Origins. Invest Ophthal Vis Sci 50:4873-4880. PMID-19420331
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Awards & Honors
2016-2020 Research to Prevent Blindness Career Development Award
2013-2015 Ruth Kirschstein National Research Service Award F32EY023496-01
2013 Edmund Optics Higher Education Grant Program finalist
2012 Schmitt Program on Integrative Brain Research Postdoctoral Fellowship
2012 ARVO Member in Training (MIT) Outstanding Poster Award
2012 Retina Research Foundation/J.M. and E.C. Lawrence Travel Award
2012-2013 Center for Visual Science Training Fellowship T32EY007125-22