color-coded orientation map of retinal blood vessels in a fundus picture. Each color shows a unique orientation/angle of a vessel

Blood Flow: Vessels of the primate retina color coded by vessel angle.

photo of capillaries of the retina

Blood Flow: The microvascular network imaged without contrast agents. The movement of single blood cells creates a spatio-temporal flicker. Motion contrast imaging reveals active perfusion in the vessels surrounding the fovea.

Green ring of cells

Ganglion Cell Function: Fluorescent ring of ganglion cells serving the foveal cones. These cells are expressing the calcium indicator GCaMP, which allows cell responses to be monitored optically.

photoreceptor mosaic

Two-photon Imaging of the Retina: Reflectance (left) and two-photon excited fluorescence (right) image of the photoreceptor mosaic in the living macaque eye. The main source of fluorescence is most likely all-trans-retinol.

loc88 montage

Two-photon Imaging of the Retina: The image shows two-photon excited fluorescence captured from photoreceptors in the living macaque eye where selective S cone damage was induced at different time points.

Color photo of capillaries of the retina

Blood Flow: A binary mask showing perfused vessels surrounding the fovea of the primate. Vessel angle is coded by color.

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Recent Publications

  • Byrne LC, Day TP, Visel M, Fortuny C, Dalkara D, Merigan WH, Schaffer DV, Flannery JG (2020). In vivo directed evolution of AAV in the primate retina. JCI Insight. doi: 10.1172/jci.insight.135112. [Epub ahead of print]. PDF
  • McGregor JE, Godat T, Dhakal KR, Parkins K, Strazzeri JM, Bateman BA, Fischer WS, Williams DR, Merigan WH (2020). Optogenetic restoration of retinal ganglion cell activity in the living primate. Nature Communications 11(1), 1703. PDF
  • Guevara-Torres A, Williams DR, Schallek J (2020). Origin of cell contrast in offset aperture adaptive optics ophthalmoscopy. Optics Letters 45(4), 840-843. PDF

more publications...