color-coded orientation map of retinal blood vessels in a fundus picture. Each color shows a unique orientation/angle of a vessel

Blood Flow: Vessels of the primate retina color coded by vessel angle.

photo of capillaries of the retina

Blood Flow: The microvascular network imaged without contrast agents. The movement of single blood cells creates a spatio-temporal flicker. Motion contrast imaging reveals active perfusion in the vessels surrounding the fovea.

Green ring of cells

Ganglion Cell Structure & Function: Fluorescent ring of ganglion cells serving the foveal cones. These cells are expressing the calcium indicator GCaMP, which allows cell responses to be monitored optically.

photoreceptor mosaic

Two-photon Imaging of the Retina: Reflectance (left) and two-photon excited fluorescence (right) image of the photoreceptor mosaic in the living macaque eye. The main source of fluorescence is most likely all-trans-retinol.

loc88 montage

Two-photon Imaging of the Retina: The image shows two-photon excited fluorescence captured from photoreceptors in the living macaque eye where selective S cone damage was induced at different time points.

Color photo of capillaries of the retina

Blood Flow: A binary mask showing perfused vessels surrounding the fovea of the primate. Vessel angle is coded by color.

Play
Pause

Recent Publications

  • Patterson SS, Cai Y, Yang Q, Merigan WH, and Williams DR. Asymmetric activation of retinal ON and OFF pathways by AOSLO raster-scanned visual stimuli. Biomed. Opt. Express 16, 2663-2691 (2025). https://doi.org/10.1364/BOE.566008
  • Shang F, Schallek J (2024). Characterization of the Retinal Circulation of the Mouse. Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):3. doi: 10.1167/iovs.65.14.3. PMID: 39620830.
  • Ashbery D, Baez HC, Kanarr RE, Kunala K, Power D, Chu CJ, Schallek J, McGregor JE; In Vivo Visualization of Intravascular Patrolling Immune Cells in the Primate Eye. Invest. Ophthalmol. Vis. Sci. 2024;65(11):23. https://doi.org/10.1167/iovs.65.11.23.

more publications...