BLOOD FLOW: Neurovascular Coupling, Hemodynamic Imaging, Imaging Pericytes.
We are developing AOSLO technology to objectively report capillary blood flow by imaging the movement of single blood cells as they flow through the capillary network. This direct and non-invasive assessment of retinal blood flow provides structural and functional information on the vascular network of the retina. We are pursuing several projects in this area: 1) examining the role of capillary level neurovascular coupling in the central nervous system 2) characterizing flow and structure parameters that describe normal vascular perfusion and 3) exploring whether aberrant blood flow patterns can serve as a preclinical biomarker of early stages of retinal disease.
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