William Merigan

Box 314
601 Elmwood Ave.
Rochester, NY 14642
Office: Medical Center G-4101
Telephone: (585) 275-4872
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My research examines the role of retinal ganglion cells in visual perception in the primate (human and macaque). The primate retina contains at least 14 different types of retinal ganglion cells, and each type forms a complete network across the retina. Because the size, shape andprojections of each of the cell types is distinctive, it is thought that they may play quite different and possibly independent roles invisual function,but at present relatively little is known about this question. Some clues about possible functions of different ganglion cell classes comes from their structure (some extend across large swaths of retina, while others get input from tiny regions of retina), their physiology (some ganglion cells respond to color, while others are color blind), and their projections into the brain (some ganglion cells project to visual cortex while others reach the superchiasmatic nucleus, which is thought to be important in diurnal rhythms).

Selected Publications

  • Aboualizadeh E, Phillips MJ, McGregor JE, DiLoreto DA Jr, Strazzeri JM, Dhakal KR, Bateman B, Jager LD, Nilles KL, Stuedemann SA, Ludwig AL, Hunter JJ, Merigan WH, Gamm DM, Williams DR (2020). Imaging Transplanted Photoreceptors in Living Nonhuman Primates with Single-Cell Resolution. Stem Cell Reports. S2213-6711(20)30240-X. doi: 10.1016/j.stemcr.2020.06.019. PDF
  • Byrne LC, Day TP, Visel M, Fortuny C, Dalkara D, Merigan WH, Schaffer DV, Flannery JG (2020). In vivo directed evolution of AAV in the primate retina. JCI Insight. doi: 10.1172/jci.insight.135112. [Epub ahead of print]. PDF
  • McGregor JE, Godat T, Dhakal KR, Parkins K, Strazzeri JM, Bateman BA, Fischer WS, Williams DR, Merigan WH (2020). Optogenetic restoration of retinal ganglion cell activity in the living primate. Nature Communications 11(1), 1703. PDF
  • Kotterman, M.A., Yin, L., Strazzeri, J.M., Flannery, J.G., Merigan, W.H., & Schaffer, D.V. (2015). Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates. Gene Therapy 22, 116–126. DOI:10.1038/gt.2014.115. PDF
  • Yang, Q., Yin, L., Nozato, K., Saito, K., Zhang, J., Merigan, W.H., Williams, D.R. & Rossi, E.A. (2015). Calibration-free sinusoidal rectification and uniform retinal irradiance in scanning light ophthalmoscopy. Opt Lett. 40(1):85-8. doi: 10.1364/OL.40.000085 PDF
  • Strazzeri JM, Hunter JJ, Masella BD, Yin L, Fischer WS, DiLoreto DA Jr, Libby RT, Williams DR, Merigan WH (2014). Focal damage to macaque photoreceptors produces persistent visual loss. Exp Eye Res 119:88-96. PDF
  • Yin L, Masella B, Dalkara D, Zhang J, Flannery JG, Schaffer DV, Williams DR, Merigan WH (2014). Imaging light responses of foveal ganglion cells in the living macaque eye. J Neurosci. ;34(19):6596-605. doi: 10.1523/JNEUROSCI.4438-13.2014. PDF
  • Sharma R, Yin L, Geng Y, Merigan W, Palczewska G, Palczewski K, Williams D, Hunter J (2013), In vivo two-photon imaging of the mouse retina. Biomed. Opt. Express 4, 1285-1293. PDF
  • Yin L, Geng Y, Osakada F, Sharma R, Cetin AH, Callaway EM, Williams DR, Merigan WH (2013). Imaging light responses of retinal ganglion cells in the living mouse eye. J Neurophysiol. 2013 Feb 13. PDF
  • Merigan W., & Pham H. (1998). V4 lesions in macaques affect both single- and multiple-viewpoint shape discriminations. Visual Neuroscience, 15(2), 359-367. PDF
  • Merigan W, Freeman A, Meyers SP (1997). Parallel processing streams in human visual cortex. Neuroreport, 8(18):3985-91. PDF
  • Lynch JJ, Silveira LCL, Perry VH, and Merigan WH (1992). Visual effects of damage to P ganglion cells in macaques. Visual Neuroscience, 8, 575-583. PDF
  • Merigan WH and Maunsell JHR (1990). Macaque vision after magnocellular lateral geniculate lesions. Visual Neuroscience, 5, 347-352. PDF

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