News + Events Archive

2020

Immune Cells

Imaging the secret lives of immune cells in the eye

Rochester researchers demonstrate way to track the interactions of microscopic immune cells in a living eye without dyes or damage, a first for imaging science.

Combining infrared videography and artificial intelligence, the new technique could be a 'game-changer' for some clinical diagnoses as well as for fields like pharmaceuticals.
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Kristen Bowles-Johnson

Kristen Bowles-Johnson received the NIH Loan Repayment Program Award

Congratulations to postdoc Kristen Bowles-Johnson, who received the NIH Loan Repayment Program Award worth $45,000.

David Williams

David Williams selected as the recipient of the David F. Weeks Award for Outstanding Vision Research by the Association of University Professors of Ophthalmology (AUPO)

Congratulations to David Williams, who has been selected as the recipient of the prestigious David F. Weeks Award for Outstanding Vision Research by the Association of University Professors of Ophthalmology (AUPO) for 2021.

The RPB David F. Weeks Award for Outstanding Vision Research recognizes and celebrates an excellent vision researcher focused on potentially blinding eye disease. The "Weeks Award" has been established through the generosity of Research to Prevent Blindness (RPB), an anonymous donor, and the AUPO, to annually recognize and celebrate an outstanding ophthalmic vision scientist whose research has made meaningful contributions to the understanding and/or treatment of potentially blinding eye disease. The award carries the name of David F. Weeks, former President and Chairman of Research to Prevent Blindness, in honor of his contributions to the field of vision research. The award will be presented at the AUPO Annual Meeting in February 2021 and carries an unrestricted award of $50,000, payable to the recipient directly and to be used at his or her discretion.

Mina Chung

Mina Chung, Retinal Surgeon and Researcher, Dies at 51

Mina Millicent Chung, M.D., an ophthalmologist and retina specialist who helped blind children to see and furthered the study of retinal disease, including macular degeneration, died Feb. 13 after a fall while skiing in Cortina d'Ampezzo, Dolomites, Italy. She was 51.

Chung was an associate professor of ophthalmology at URMC's Flaum Eye Institute and a faculty member in the University's Center for Visual Science. Before being recruited to Rochester in 2002, she completed a fellowship in vitreoretinal surgery at the University of Iowa College of Medicine, following residency and postdoctoral research at USC University Hospital in Los Angeles, where she served as chief resident from 2000 to 2002. Chung was a 1994 graduate of the Yale University School of Medicine who received her undergraduate degree from Yale in 1990.
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2019

David DiLoreto

David DiLoreto Jr. Selected to Chair University of Rochester Medical Center Department of Ophthalmology, Lead Flaum Eye Institute

David A. DiLoreto, Jr., M.D., Ph.D., was named chair of the University of Rochester Medical Center's Department of Ophthalmology and director of the Flaum Eye Institute, pending approval by the Office of the Provost. He succeeds Chair Steven Feldon, M.D., M.B.A., who will transition to associate vice president and director of the Office of Biomedical Research Development.
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Tyler Godat

Tyler Godat receives OSA FVM Young Investigator Award

Congratulations to Tyler Godat, who received the Optical Society of America Fall Vision Meeting Young Investigator Award for his presentation last Saturday in Washington DC. Tyler spoke about "In vivo classification of macaque foveal ganglion cells through optical recording of responses to chromatic and luminance flicker."

blood cells

Credit: Pixabay

ARIA on the Naked Scientist Podcast

Aby Joseph, Andres Guevara-Torres, and Jesse Schallek present on the Naked Scientist podcast (Start: 13:19 / End: 20:22). Read more...

L-R: Schallek, Guevara-Torres, Joseph

Imaging That Twinkle in Your Eye: Assessing Vascular Health by Imaging Blood Cells in the Retina

Aby Joseph, Andres Guevara, and Jesse Schallek describe a new, noninvasive approach to assess vascular health in the journal eLife. Schallek's lab, part of the Flaum Eye Institute, developed a method to visualize how single blood cells flow through vessels of the eye using adaptive optics imaging.
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Sarah Walters defense poster

Congratulations to Dr. Sarah Walters, for her successful PhD defense

Congratulations to Dr. Sarah Walters, for her successful PhD Defense, "Two-Photon Excited Fluorescence Adaptive Optics Ophthalmoscopy of Retinal Function." Advised by Prof. Jennifer Hunter & Prof. David Williams

Abstract: The retina is the light-sensitive tissue at the back of the eye, which carries out the first steps in vision. Specialized neural cells in the retina known as photoreceptors are responsible for detection of light and its transduction by initiating an electrical signal to the brain. Adaptive optics scanning light ophthalmoscopy (AOSLO), which dynamically corrects aberrations of the ocular media in the living eye and affords a lateral resolution of 2 μm, has revolutionized our ability to visualize photoreceptors and many other microstructures in the retina. The implementation of two-photon excited fluorescence (TPEF) imaging in AOSLO has enabled not only complementary structural information throughout the retina, but an objective, non-invasive measure of visual function in photoreceptors by measuring TPEF kinetics from these cells.

The aim of the present thesis is to further develop and apply TPEF ophthalmoscopy as a novel measure of in vivo cellular function in the retina. First, TPEF ophthalmoscopy was used in conjunction with other imaging modalities to evaluate the extent of photoreceptor dysfunction in a non-human primate model of retinal degeneration. TPEF ophthalmoscopy was essential in determining that photoreceptors were non-functional. Second, the sensitivity of TPEF kinetics to detect changes in photoreceptor function in conditions relevant to disease pathogenesis was investigated. Systemic hypoxia was employed in non-human primates as a model of physiological change, reducing oxygen supply to the retina, and TPEF kinetics were shown to be slowed as a consequence. Finally, the capabilities of TPEF ophthalmoscopy were expanded by implementing intrinsic fluorescence lifetime imaging. TPEF lifetime imaging was shown to distinguish retinal cell classes that are functionally disparate, and lifetimes were altered in regions of retinal damage.

TPEF ophthalmoscopy has the potential to yield advances in understanding of both the basic physiology and pathology of the retina. If translated successfully into humans, TPEF ophthalmoscopy demonstrates promise as a valuable imaging modality that may, when used in conjunction with other clinical measures, identify early cellular dysfunction and longitudinally track pathological changes. Ultimately, it may assist in timely diagnosis, intervention, and development of treatments or vision restoration methods to combat blindness as a consequence of retinal disease.

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